If you’ve ever had problems with regulating your blood sugar, READ THIS.
A new study with baby fat cells (3T3-L1 cells) demonstrates that E3 (estriol) activates the genes that make visfatin, a hormone that comes from fat that helps to regulate blood sugar. That may not mean a lot to you yet, but once you read this short handout, it will. This study has far-reaching implications for women, as a tool, to help maintain healthier blood sugar levels.
Visfatin, like leptin, is a hormone produced by your FAT cells. The primary hormone produced in fat cells that regulates blood sugar is called adiponectin.
Since Visfatin is a hormone, it appears to help blood sugar metabolism under forms of potential stress. For example, as your abdominal size increases - visfatin levels rise, seemingly to help you metabolize blood sugar in the presence of being too FAT.
Similarly, Visfatin levels rise during pregnancy to help regulate your blood sugar during the pregnancy as extra weight is gained. When you lose your extra pounds of stomach FAT or after the weight gain of pregnancy is gone - then your Visfatin levels return to normal.
The new research shows that E3 (estriol) is the key hormone that activates Visfatin production during pregnancy, and its production is synergistically enhanced by Progesterone and E2 estradiol (but not activated by these other two sex hormones).
This means that women lacking in E3 (estriol) the good estrogen type hormone or (progesterone) during pregnancy are much more at risk for gestational diabetes.
However, E3 (estriol) levels, as well as (progesterone) levels, decline with age and often take a jolt after menopause. That’s the main reason you need a topical hormone crème like E3 (estriol).
Additionally, women who have had one or both ovaries removed will NOT make E3 (estriol) at the proper rate, so you definitely need to use a topical E3 (estriol) creme.
Women have a higher percentage of body FAT than men, so it makes sense that they have a way to regulate their blood sugar in the presence of this higher natural level of body FAT: it appears E3 (estriol) is the primary answer and progesterone is the secondary support to the E3 (estriol). I suggest you use both.
This study supports the theory that a decline in E3 (estriol) due to aging (or surgery) contributes to insulin resistance, abdominal weight gain, and a rise in fasting blood sugar levels. Both these crèmes are available at this office and you might be a candidate.